Gene-edited stem cells help geckos regrow more perfect tails

Regenerating body parts is never easy. For instance, some lizards can grow back their tails, but these new appendages are pale imitations of the original. Now, genetically modified stem cells are helping geckos grow back better tails.

Tweaking and implanting embryonic stem cells on the tail stumps of mourning geckos (Lepidodactylus lugubris) allowed the reptiles to grow tails that are more like the original than ever before, researchers report October 14 in Nature Communications. These findings are a stepping-stone to developing regenerative therapies in humans that may one day treat hard-to-heal wounds.

A gecko’s tail is an extension of its spine — with the vertebrae to prove it. Regenerated tails, however, are simpler affairs. “It’s just a bunch of concentric tubes of fat, muscle and skin,” says Thomas Lozito, a biologist at the University of Southern California in Los Angeles.

That’s because stem cells in adult geckos produce a molecular signal that encourages the formation of cartilage in new tails, but not bone or nervous tissues (SN: 8/17/18). Lozito and his colleagues used embryonic stem cells, which can develop into a wider range of tissues than adult stem cells, modified them to ignore this signal and then implanted them on the tail stumps of geckos that had their tails surgically removed. The tails that grew from these modified stem cells had bonelike grooves in the cartilage and generated new neural tissue at the top of the tail.

These modified tails still lack a spinal cord, making them a far cry from the original. “We fixed one problem, but there are still many imperfections,” Lozito says. “We’re still on the hunt for the perfect tail.”

What channel is Formula 1 on today? TV schedule, start time for 2021 Qatar Grand Prix

And then there were three.

Just three races in the 2021 Formula 1 world championship remain, and it looks like Red Bull's Max Verstappen is in the driver's seat to secure his first world driver's championship.
But hot on his tail is still Lewis Hamilton, who took home the victory in the Brazilian Grand Prix to once again tighten the gap at the top between he and Verstappen entering the final three sprints of the season.
To say "hot on his tail" would maybe be a bit of an undersell. Hamilton put together a fantastic trio of drives during the weekend, from qualifying to sprint qualifying to the race, starting in 10th and ending up first, even after taking a five-spot grid penalty for a violation.

It doesn't get much hotter than Qatar — or the 2021 F1 championship.

Here's what you need to know about this weekend's F1 race:

What channel is the F1 race on today?
Race: Qatar Grand Prix
Date: Sunday, Nov. 21
TV channel: ESPN 2
Live stream: fuboTV
The ESPN family of networks will broadcast all 2021 F1 races in the United States using Sky Sports' feed, with select races heading to ABC later in the season.

ESPN Deportes serves as the exclusive Spanish-language home for all 2021 F1 races in the U.S.

What time does the F1 race start today?
Date: Sunday, Nov. 21
Start time: 9 a.m. ET
The 9 a.m. ET start time for Sunday's race means the 2021 Qatar Grand Prix will start at 5 p.m. local time. Lights out will likely take place just after 9 a.m. ET. ESPN's prerace show usually airs in the hour before the start of the race.

Below is the complete TV schedule for the weekend's F1 events at the Qatar Grand Prix. All times are Eastern.

Date Event Time TV channel
Friday, Nov. 19 Practice 1 5:30 a.m. ESPN2
Friday, Nov. 19 Practice 2 9 a.m. ESPN2
Saturday, Nov. 20 Practice 3 6 a.m. ESPN2
Saturday, Nov. 20 Qualifying 9 a.m. ESPN2
Sunday, Nov. 21 Race 9 a.m. ESPN2
Formula 1 live stream for Qatar Grand Prix
For those who don't have a cable or satellite subscription, there are five major OTT TV streaming options that carry ESPN — fuboTV, Sling, Hulu, YouTubeTV and AT&T Now. Of the five, Hulu, fuboTV and YouTubeTV offer free-trial options.

Below are links to each.
For those who do have a cable or satellite subscription but are not in front of a TV, Formula 1 races in 2021 can be streamed live via phones, tablets and other devices on the ESPN app with authentication.

Formula 1 schedule 2021
In all, there are 23 scheduled races in the 2021 F1 season, with the Portuguese Grand Prix sliding onto the docket the first week in March. The originally scheduled Vietnam Grand Prix was removed after the arrest of Nguyen Duc Chung, while the Chinese Grand Prix is up in the air. It was originally scheduled for April 11 but will likely not take place this season.

The Singapore Grand Prix was also removed from the schedule, with the Turkish Grand Prix returning to the schedule in its stead.

All races will be broadcast in the U.S. on the ESPN family of networks, with the United States Grand Prix and Mexico City Grand Prix both airing on ABC.

Please note: The on-the-hour start times do not include the broadcast start time, which is typically five minutes before the start of the race. Times do not include ESPN's customary prerace shows.

MORE: Live stream F1 races all season on fuboTV (7-day free trial)

Here's the latest schedule:

Date Race Course Start time (ET) TV channel Winner
March 28 Bahrain Grand Prix Bahrain International Circuit 11 a.m. ESPN2 Lewis Hamilton (Mercedes)
April 18 Emilia Romagna Grand Prix Autodromo Internazionale Enzo e Dino Ferrari 9 a.m. ESPN Max Verstappen (Red Bull)
May 2 Portuguese Grand Prix Algarve International Circuit 10 a.m. ESPN Lewis Hamilton (Mercedes)
May 9 Spanish Grand Prix Circuit de Barcelona-Catalunya 9 a.m. ESPN Lewis Hamilton (Mercedes)
May 23 Monaco Grand Prix Circuit de Monaco 9 a.m. ESPN2 Max Verstappen (Red Bull)
June 6 Azerbaijan Grand Prix Baku City Circuit 8 a.m. ESPN Sergio Perez (Red Bull)
June 20 French Grand Prix Circuit Paul Ricard 9 a.m. ESPN Max Verstappen (Red Bull)
June 27 Styrian Grand Prix Red Bull Ring 9 a.m. ESPN Max Verstappen (Red Bull)
July 4 Austrian Grand Prix Red Bull Ring 9 a.m. ESPN Max Verstappen (Red Bull)
July 18 British Grand Prix Silverstone Circuit 10 a.m. ESPN Lewis Hamilton (Mercedes)
Aug. 1 Hungarian Grand Prix Hungaroring 9 a.m. ESPN Esteban Ocon (Alpine)
Aug. 29 Belgian Grand Prix Circuit de Spa-Francorchamps 9 a.m. ESPN2 Max Verstappen (Red Bull)
Sept. 5 Dutch Grand Prix Circuit Zandvoort 9 a.m. ESPN2 Max Verstappen (Red Bull)
Sept. 12 Italian Grand Prix Autodromo Nazionale di Monza 9 a.m. ESPN2 Daniel Ricciardo (McLaren)
Sept. 26 Russian Grand Prix Sochi Autodrom 8 a.m. ESPN2 Lewis Hamilton (Mercedes)
Oct. 10 Turkish Grand Prix Intercity Istanbul Park 8 a.m. ESPN2 Valtteri Bottas (Mercedes)
Oct. 24 United States Grand Prix Circuit of the Americas 3 p.m. ABC Max Verstappen (Red Bull)
Nov. 7 Mexico City Grand Prix Autodromo Hermanos Rodriguez 2 p.m. ABC Max Verstappen (Red Bull)
Nov. 14 São Paulo Grand Prix Autodromo Jose Carlos Pace Noon ESPN2 Lewis Hamilton (Mercedes)
Nov. 21 Qatar Grand Prix Losail International Circuit 9 a.m. ESPNews TBD
Dec. 5 Saudi Arabian Grand Prix Jeddah Street Circuit 11 p.m. ESPN2 TBD
Dec. 12 Abu Dhabi Grand Prix Yas Marina Circuit 8 a.m. ESPN2 TBD

Will the Wizards be a playoff team? Washington surrenders first place in the Eastern Conference

The Washington Wizards got out to as good of a start as any team in the NBA, shocking the masses to take first place in the Eastern Conference through the first month of the season.

Following Thursday's loss to the Miami Heat, the Wizards have surrendered their spot atop of the East, failing to pick up a win in one of their toughest tests early on.
They still own a strong 10-5 record and have some quality wins on their resume – they beat both of last year's Conference Finalists in the Atlanta Hawks and Milwaukee Bucks, the Boston Celtics twice, the Toronto Raptors on the road and a blowout win over the Memphis Grizzlies. But along with the loss to the Heat, they also failed tests against the Brooklyn Nets and Charlotte Hornets.

With almost an entirely new roster following the trade that sent Russell Westbrook to the Los Angeles Lakers, the Wizards pieces have clicked quickly.

Is this team good enough to make the playoffs, though? Three members of our Sporting News staff discuss.
Will the Wizards be a playoff team?
Kyle Irving (@KyleIrv_): I'm a believer. The Wizards will be a playoff team.

Going into the season, I thought this was just a roster of misfit toys. Returning Kyle Kuzma, Montrezl Harrell and Kentavious Caldwell-Pope in the trade for Westbrook and signing Spencer Dinwiddie, they brought in four solid players, but I wasn't convinced it was a group who could make any noise in the improving East.

Turns out, I was very wrong. Yes, they've failed a few tough tests, but they've also beaten some good teams.

Harrell looks like the player who won Sixth Man of the Year back in 2018-19, averaging over 17 points and eight rebounds per game with five double-doubles in 15 games. Kuzma is thriving in a new situation with a bigger role, nearly averaging a double-double, and Dinwiddie has complimented Bradley Beal perfectly in the backcourt.

They also have dealt with a handful of injuries and absences, and their starting forward and former lottery pick Rui Hachimura hasn't even taken the floor yet for personal reasons.

The craziest part is after being one of the worst defensive teams in the NBA last season, new head coach Wes Unseld Jr. has this team ranked in the top-five in the league in defensive rating so far.

There's still a lot of basketball to be played this year, but I don't see why Washington can't maintain this hot start and stay in the playoff picture.
Yash Matange (@yashmatange2694): Despite the loss in Miami, which is now three straight for the Wizards, I believe they are a playoff team.

They might not go too far in the postseason but I believe they could make it to the playoffs by avoiding the Play-In Tournament. I see them finishing behind the Heat, Nets, Bulls, Bucks and maybe the Celtics or Hawks (whichever makes the better recovery after their rough start) in the East standings.

Their depth, acquired as a result of the Westbrook trade this past offseason, is a huge reason why they have done so well. Players from that trade like Harrell (bringing it every night off the bench), Kuzma (high-volume rebounding, small-ball big), Dinwiddie (good complementary guard to Beal), Caldwell-Pope (3-and-D wing) and Aaron Holiday (bench guard) have all played key roles in the team's games so far, especially the wins.
Why I believe the Wizards can carry this form all through the regular season is the play of Beal. While the 2021 All-NBA player is scoring 23.4 (through 11 games) on shooting splits of 41.1 percent from the field and 28.0 from beyond the arc, it's nowhere close to his level from last year when he averaged a near league-high 31.3 points on 48.5 percent shooting from the field and 34.9 percent from beyond the arc.

His slump (if you want to call it that) is on track with a few other superstars finding their way with the new ball and officiating rules. So, I see him bouncing back.

Also, I have to give a huge shoutout to Unseld Jr., a coach with 16 years of experience as an assistant, for making this team with tremendous depth click. Of course, GM Tommy Shepherd as well. Having said that, with the East being top-heavy, I don't see them going too far in the postseason. If everything falls their way in a best-case scenario, it could be a Conference Semifinals appearance. Otherwise, I see them bowing out in the first round.
Nick Metallinos (@NickMetallinos): It’s still early in the season, and I will wait until I’ve seen more to make a final call, but the Wizards' loss to the Heat is another example of coming up short against championship level opponents in 2021-22. I think they're a playoff team, but they won't make any noise when they get there.

As mentioned in the intro, two of the team’s five losses have been against the Nets and Heat, two certified powerhouses in the East.

However, they will continue to be steady throughout the regular season because they are getting contributions evenly from their roster. From Beal to Kuzma to Dinwiddie, they’re getting solid offensive numbers, but once the postseason begins they’re going to need more firepower than that.

Their defense is currently fourth-best in the league in terms of defensive rating, but they will definitely need more offense when teams inevitably focus on slowing down Beal on the road to the playoffs.

The next Derrick Rose? Paul George sees greatness in Ja Morant

Grizzlies star Ja Morant has earned a lot of attention early on in the 2021-22 season, and rightfully so.

The 22-year-old has taken a monster leap from Year 2 to Year 3, looking like a player who is aiming higher than just a Most Improved Player of the Year award or the first All-Star bid of his career.
He is, of course, arguably the frontrunner for Most Improved and is well on his way to an All-Star nod, but Morant's name was a part of even bigger conversations through the first couple weeks of the season. It was a small sample size, but Morant started to carve a realistic path to an MVP trophy. And although that momentum has decelerated as we get further into the season – primarily because the Grizzlies might not win enough games for him to truly be considered – Morant has still earned that level of respect from his peers.
After the last time Morant faced off against the Clippers, a game in which he had 28 points and eight assists in a win, All-Star forward Paul George couldn't help but compare the No. 2 overall pick to a former MVP in Derrick Rose.

"He’s just explosive, electrifying," George said of Morant. "I’d compare him to like, D-Rose. I guarded him my rookie year, Indy-Chicago, and guarding Ja is very similar to how D-Rose was.

"It was just how quick and his ability to change direction, move his body in-air," George continued. "He made it tough for us. He put a lot of pressure on us. He’s explosive. You know the direction he wants to go. He wants to go left, we knew that, but he’s just so good and so fast, he still gets to it."

It's hard to argue with the comparison and when you actually line them up side-by-side, it gets even scarier.

When Rose became the youngest MVP in league history back in 2010-11, it was his age 22 season and third year in the league. Morant entered this season at 22 years old, marking his third in the league.

Their numbers during their third season are almost identical, too.

Comparing Ja Morant's 2021-22 season to Derrick Rose's MVP season
Year GP PPG APG RPG SPG FG% 3P% FT%
Derrick Rose 2010-11 81 25.0 7.7 4.1 1.0 44.5 33.2 85.8
Ja Morant 2020-21 14 25.9 7.3 5.1 1.6 49.3 38.2 77.5
Morant has only played 14 games and would obviously have to keep up this production over the course of an entire season the way Rose did, but still, he's on quite the trajectory.

As George did, you could use these same adjectives to describe both players: explosive, electrifying, shifty and athletic. They both even have that same killer instinct, never shying away from a big moment.

I mean, who is the first player that comes to mind when you see dunks like this:

What about drives like this, where he's changing direction, changing speed, floating in the air and still finding a way to finish amongst the trees:

You'll see a whole lot of those same moves in any season-long highlight tape from Rose back in 2010-11.

Even if Morant can't match Rose as a 22-year-old MVP, it's looking like the star guard will see his name in those types of discussions for many years to come with the potential to win the league's most prestigious individual award at some point down the line.

College football coach carousel: Every FBS coaching change in 2021

The 2021 FBS coaching carousel is moving fast, and we're just starting November.

Virginia Tech coach Justin Fuente was fired on Tuesday after six seasons. Fuente is the 12th coaching change in the 2021 season. That list includes seven Power 5 openings. Washington's Jimmy Lake was fired on Sunday.
There were 18 coaching changes last season, a number that likely will be surpassed given how many we've seen so far.

Sporting News looks at all the changes in 2021:

2021 FBS coaching changes
Randy Edsall, UConn
Resigned (Sept. 6): Edsall resigned after the Huskies' 0-2 start. Edsall had two separate stints at UConn. The first, from 1999 to 2010, saw the program make the rise to the FBS ranks and culminated with a trip to the Fiesta Bowl in 2010. Edsall returned in 2017, and that produced a 6-32 record. UConn did not play in 2020 because of COVID-19 concerns. Lou Spanos is the Huskies' interim coach.

Clay Helton, USC
Fired (Sept. 14): Helton, who had been on the hot seat the past few seasons, was fired after the Trojans' 42-28 loss to Stanford in Week 2. Helton replaced Steve Sarkisian in 2015 and compiled a 46-24 record. That mark included the program's last Pac-12 championship in 2017. USC, however, slipped to a 19-14 record from 2018-21. Donte Williams replaced Helton as interim coach.
Chad Lunsford, Georgia Southern
Fired (Sept. 26): Lunsford was fired after a 1-3 start this season. It was a peculiar decision considering the Eagles reached bowl games the previous three seasons. Lunsford compiled a 28-21 record and had previously been an assistant coach with the program from 2013-17. Kevin Whitley was appointed interim coach.

2021 Coaching changes by school
SCHOOL FIRED/RESIGNED REPLACEMENT
UConn Randy Edsall Jim Mora
USC Clay Helton
Georgia Southern Chad Lunsford Clay Helton
LSU Ed Orgeron
Washington State Nick Rolovich
Texas Tech Matt Wells Joey McGuire
TCU Gary Patterson
Akron Tom Arth
UMass Walt Bell
Washington Jimmy Lake
FIU Butch Davis
Virginia Tech Justin Fuente
Ed Orgeron, LSU
Resigned (Oct. 19): Orgeron and LSU reached a separation agreement that will take effect after the conclusion of the 2021 season. This came one day after the Tigers beat Florida 49-42. Orgeron replaced Les Miles in 2016 and became the third consecutive LSU coach to win a national championship (2019). The Tigers finished 15-0 with Heisman Trophy winner Joe Burrow that year, but the program has been a disaster on and off the field since. The problems include a Title IX lawsuit and self-imposed penalties.

Nick Rolovich, Washington State
Fired (Oct. 20): Rolovich was fired in his second season with the Cougars for failing to comply with the state's COVID-19 vaccine mandate. Rolovich cited religious beliefs for his reason to not get the vaccine, and he plans to sue the university over his firing . Rolovich, who previously coached at Hawaii, had a 5-6 record at Washington State. Jake Dickert replaced Rolovich on an interim basis.
Matt Wells, Texas Tech
Fired (Oct. 25): Wells was fired after a 25-24 loss to Kansas State on Oct. 23, which capped an unremarkable three-year stint with the Red Raiders. Wells replaced Kliff Kingsbury, who took a head coaching job in the NFL with the Cardinals. Wells compiled a 13-17 record but appeared to have Texas Tech headed in the right direction this year with a 5-2 start. Sonny Cumbie, a former Red Raiders quarterback, is the interim coach.

Gary Patterson, TCU
Resigned (Oct. 31): Patterson and TCU agreed to part ways after a 3-5 record through the first two months of the season. It's still a somewhat shocking move considering he was the second-longest tenured coach in the FBS behind Iowa's Kirk Ferentz. Patterson took over the Horned Frogs in 2000, and he led the program to six conference championships and 11 seasons with 10 wins or more. The highlight was 2010, when TCU finished 13-0 and won the Rose Bowl. The Horned Frogs moved up to the Big 12 and enjoyed success in the Power 5.

Tom Arth, Akron
Fired (Nov. 4): Arth was fired two days after a 31-25 loss to Ball State dropped the Zips to 2-7 in 2021. Arth, a nearby John Carroll alum, simply could not get Akron going in three seasons. The Zips had a 3-24 record in that stretch, including a 3-17 record in Mid-American Conference play.

Walt Bell, UMass
Fired (Nov. 8): Bell was fired after a 35-22 loss to Rhode Island on Nov. 6. Bell, who took the UMass job after a stint as an offensive coordinator at Florida State, had a 2-23 record since taking over in 2019.

Jimmy Lake, Washington
Fired (Nov. 14): Lake was already under a university suspension for hitting Huskies linebacker Ruperake Fuavai in the helmet druing a game. He did not coach the Huskies' loss to Arizona State on Nov. 13. Earlier that day, The Seattle Times published an article that contained allegations Lake shoved former wide receiver Quinten Pounds into a locker at halftime of a 2019 game at Arizona. Lake denied the allegations. Washington was 7-6 under Lake. Assistant coach Bob Gregory was named interim head coach.

Butch Davis, FIU
Fired (Nov. 15): Davis will not return to FIU when his contract expires at the end of this season. The decision comes a week after longtime FIU athletic director Pete Garcia resigned. Davis said the school administration is "sabotaging the program." Davis, who previously coached at Miami and North Carolina, had success in his first two seasons at FIU. The program slipped the last two years, however, and is 1-9 in 2021.

Justin Fuente, Virginia Tech
Fired (Nov. 16): Fuente is out after six seasons with the Hokies. Fuente, who was hired in 2016 after a three-year stint in Memphis, enjoyed a 10-4 season and an appearance in the ACC championship game in his first season. The Hokies are 24-23 the last four years, however, and they have been a middle-of-the-road program in the ACC Coastal Division. Fuente finshed with a record of 43-31.